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Acomplia (Rimonabant / Zimulti) is The new weight loss medication breakthrough from Sanofi-Aventis , exceeding Phentermine in itÂ’s ability to help you lose the weight! It is a CB1 cannabinoid receptor antagonist ,and Its main avenue of effect is reduction in appetite. Acomplia acts by obstructing the receptors, which control the food intake and energy expenditure - Thus resulting in reduced appetite. Acomplia also has an added characteristic effect as a smoking cessation aid.